The revolutionary blood test that could predict how long you'll live, what ailments you'll get - and how fast you'll age
- Chemical 'fingerprint' in the blood could provide clues to health later in life
- Metabolites indicate future lung function, bone density, and blood pressure
- Could pave the way for new treatments for age related conditions
A revolutionary new blood test could tell you how long you will live, and how quickly you will age.
Scientists
have discovered a chemical ‘fingerprint’ in the blood that may provide
clues to an infant's health and rate of ageing near the end of life.
The discovery raises the prospect of a simple test at birth that could help doctors stave off the ravages of disease in old age.
A revolutionary new blood test could tell you
how long you will live, and how quickly you will age, thanks to a
chemical 'fingerprint' in your blood
It could lead to the development of powerful new treatments for age related conditions such as bone problems and heart disease.
Scientists
identified 22 metabolites, small molecules linked to metabolism, that
may be useful indicators of how we can expect to grow old.
One
in particular, linked to a range of traits including lung function,
bone density, blood pressure and cholesterol levels, was singled out by
the researchers.
It is also strongly associated with birth weight - itself a known determinant of healthy ageing.
Levels of this metabolite, C-glyTrp, could reflect accelerated ageing in later adulthood, the scientists believe.
Higher levels of the molecule were associated with lower weight at birth in comparisons between pairs of identical twins.
The discovery raises the prospect of a simple test at birth that could help doctors stave off the ravages of disease in old age
Since identical twins share the same
genes, this suggests that levels of the metabolite are altered by
nutrition or different conditions in the womb.
Study
leader Professor Tim Spector, from King's College London, said:
‘Scientists have known for a long time that a person's weight at the
time of birth is an important determinant of health in middle and old
age, and that people with low birth weight are more susceptible to age
related diseases.
‘So far
the molecular mechanisms that link low birth weight to health or disease
in old age had remained elusive, but this discovery has revealed one of
the molecular pathways involved.’
Professor Spector's team analysed blood samples donated by more than 6,000 twins.
The
researchers identified 22 metabolites directly linked to chronological
age, with higher concentrations in older than in younger people.
Further
work showed that the gene influencing levels of C-glyTrp could be
modified by epigenetics, a process whereby environmental factors switch
genes on or off and alter their activity.
The
epigenetic changes may influence metabolism during a person's lifetime,
thereby affecting susceptibility to age-related diseases.
The findings are published today in the International Journal of Epidemiology.
Co-author
Dr Ana Valdes, also from King's College London, said: ‘Human ageing is a
process influenced by genetic, lifestyle and environmental factors, but
genes only explain a part of the story.
‘Molecular
changes that influence how we age over time are triggered by epigenetic
changes. This study has for the first time used analysis of blood and
epigenetic changes to identify a novel metabolite that has a link to
birth weight and rate of ageing.
‘This
unique metabolite, which is related to age and age-related diseases,
was different in genetically identical twins that had very different
weight at birth. This shows us that birth weight affects a molecular
mechanism that alters this metabolite.
‘This
may help us understand how lower nutrition in the womb alters molecular
pathways that result in faster ageing and a higher risk of age-related
diseases 50 years later.
'Understanding
the molecular pathways involved in the ageing process could ultimately
pave the way for future therapies to treat age-related conditions.
‘As
these 22 metabolites linked to ageing are detectable in the blood, we
can now predict actual age from a blood sample pretty accurately and in
the future this can be refined to potentially identify future rapid
biological ageing in individuals.’
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